Amphetamine Synthese (Photo Documented, v1.0).pdf

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Complete amphetamine synthese.

This is everything you need for making P2NP, from left to right:

Pipette-aparatus, several pipettes, dean&stark trap, PTFE greas, toluene, measuring cylinder

100ml, nitroethane, benzaldehyde, n-butylamine, above the brown flask a heating mantle and

a 250ml RB-flask.

The ratio s you should use are 1mol benzaldehyde and 1 mol nitroethane and 0,1mol R-NH2.

Converting mols to ml s you will find out that you will need:

SWIM didn t use 1 mol right away but first wanted to experiment with smaller amounts, so he

used:

17ml benzaldehyde

13,3ml nitroethane

3,3ml n-butylamine

33ml toluene

Be sure that non of the products you use will contain water since when performing the

reaction water will evolve which will be taken out of the reaction with the dean&stark trap

because it prevents a good yield of P2NP.

All the chemicals mixed together.

An overall view

After heating it a bit to get it at 100*C aprox.

A vague picture of how it looks like after 3 hours of refluxing,

if the color will get orange to dark orange before 6 hours you should stop refluxing at that

time.

But don t reflux it longer than 6 hours, sometimes you only need 3 hours though.

To improve yield you can also add 1ml of glacial acetic acid to buffer the n-butylamine.

For every mole of benzaldehyde one mole of water will form and since SWIM used 17ml of

benzaldehyde which is ( 17ml x 1,05g/ml = 17,85g benzaldehyde / 106,12g/mol = ) 0,17mol

benzaldehyde. Thus 0,17 mol of water will form which is ( 0,17 x 18,01 = ) 3,03ml of water.

So after the 6 hours or earlier you should have 3,03ml of water in your trap, it will likely be

more since your toluene will contain a bit of water too in SWIMS reaction he got 4ml of water.

The color after 6 hours of refluxing and collecting 4ml of water in the trap.

Now SWIM puts the round bottom flask in the freezer at 18*C because the P2NP is now

dissolved in the toluene but when you will make the toluene very cold the P2NP won t dissolve

in the toluene anymore or at least very bad.

7 hours later scratched the walls of the RB flask to initiate crystal forming.

10 hours later a lot of crystals in the RB flask,

The crop of crystals in the bottom of the flask.

Crystals formed on the sides.

Now quickly break up the mass with a glass stir rod or a thermometer and throw the mixture

threw a buchner filter (filtration under vacuum).

The toluene will get back to room temperature and thus the crystals will dissolve back into the

toluene that is why you need to be so quick and necesarilly do need to use a buchner filter.